[Randy Holmes-Farley]

Publications


ISSUED UNITED STATES PATENTS

1. Fat-binding polymers Holmes-Farley; Stephen Randall US 7,049,345 May 23, 2006.

2. Aryl boronic acids for treating obesity Holmes-Farley; Stephen Randall; Mandeville, III; W. Harry; Dhal; Pradeep K.; Huval; Chad Cori; Li; Xinhua US 7,049,345 May 23, 2006.

3. Fat-binding polymers Jozefiak; Thomas; Holmes-Farley; Stephen Randall; Mandeville, III; W. Harry; Huval; Chad Cori; Garigapati; Venkata R.; Shackett; Keith K.; Concagh; Danny US 7,048,917 May 23, 2006.

4. Aryl boronate functionalized polymers for treating obesity Holmes-Farley; Stephen Randall; Mandeville, III; W. Harry; Dhal; Pradeep K.; Huval; Chad Cori ; Li; Xinhua Polomoscanik; Steven Craig US 7,041,280 May 9, 2006.

5. Phosphate-binding polymers for oral administration Holmes-Farley; Stephen Randall; Manderville, III; W. Harry; Whitesides; George M. US 7,014,846 March 21, 2006.

6. Aryl boronic acids for treating obesity Holmes-Farley; Stephen Randall; Mandeville, III; W. Harry; Dhal; Pradeep K.; Huval; Chad Cori; Li; Xinhua US 6,858,592 February 22, 2005.

7. Method of making phosphate-binding polymers for oral administration. Holmes-Farley, Stephen Randall; Mandeville, W. Harry, III; Whitesides; George M. US 6,858,203; 2/22/2005.

8. Process for removing bile salts from a patient and alkylated compositions therefore. Mandeville, W. Harry, III; Holmes-Farley, Stephen Randall. US 6,784,254; 8/31/2004.

9. Ionic polymers as anti-infective agents. Mandeville, W. Harry, III; Neenan, Thomas X.; Holmes-Farley, Stephen Randall. US 6,767,549; 7/27/2004.

10. Fat-binding polymers; Jozefiak, Thomas; Holmes-Farley, Stephen Randall; Mandeville, W. Harry, III; Huval, Chad Cori; Garigapati, Venkata R.; Shackett, Keith K.; Concagh, Danny. US 6,726,906; 4/27/2004.

11. Poly (diallylamines)-based phosphate binders; Mandeville, W. Harry, III; Holmes-Farley, Stephen Randall. US 6,726,905; 4/27/2004.

12. Poly(diallylamine)-based bile acid sequestrants. Holmes-Farley, Stephen Randall; Dhal, Pradeep K.; Petersen, John S. US 6,610,283; 8/26/2003.

13. Iron-binding polymers for oral administration. Mandeville, W. Harry, III; Holmes-Farley, Stephen Randall. US 6,605,270; 8/12/2003.
14. Ionic polymers as anti-infective agents. Mandeville, W. Harry, III; Neenan, Thomas X.; Holmes-Farley, Stephen Randall. US 6,593,366; 7/15/2003.
15. Method for reducing oxalate. Holmes-Farley, Stephen Randall; Mandeville, III; W. Harry. US 6,566,407; 5/20/2003

16. Polyether-based bile acid sequestrants. Holmes-Farley, Stephen Randall; Huval, Chad Cori. U.S. 6,517,825; 2/11/2003.

17. Method of making phosphate-binding polymers for oral administration. Holmes-Farley, Stephen R.; Mandeville, W. Harry, III; Whitesides; George M. U.S. 6,509,013; 1/21/2003.

18. Combination therapy for treating hypercholesterolemia using a bile acid sequestrant polymer and a cholesterol-lowering agent. Huval, Chad Cori; Holmes-Farley, Stephen Randall; Petersen, John S.; Dhal, Pradeep K. U.S. 6,433,026; 8/13/2002.

19. Method for treating hypercholesterolemia with polyallylamine polymers. Holmes-Farley, Stephen Randall; Mandeville, W. Harry, III; Burke, Steven K.; Goldberg, Dennis I. , US 6,423,754; 7/23/2002.

20. Ionic polymers as anti-infective agents Mandeville, W. Harry, III; Neenan, Thomas X..; Holmes-Farley, Stephen Randall;, US 6,395,777; 5/28/2002.

21. Combination therapy for treating hypercholesterolemia and atherosclerosis. Huval, Chad Cori; Holmes-Farley, Stephen Randall; Petersen, John S.; Dhal, Pradeep K. U.S. 6,365,186; 4/2/2002.

22. Fat binding polymers. Jozefiak, T.; Holmes-Farley; S. R.; Mandeville, W. H., III; Huval; C. C.; Garigapati, V. R.; Shackett, K. K.; Concagh, D, US 6,299,868; 10/9/2001.

23. Polymers containing guanidinium groups as bile acid sequestrants. Dhal; P. K.; Holmes-Farley; S. R.; Petersen; J. S. US 6,294,163; 9/25/2001

24. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville, W. H., III.; US 6,281,252; 8/28/2001.

25. Combination therapy for treating hypercholestrolemia. Huval; C. C.; Holmes-Farley; S. R. ; Petersen; J. S.; Dhal; P. K. ; US 6,264,938; 7/24/2001.

26. Fat-binding polymers. Mandeville, W. H., III.; Whitesides, G. M.; Holmes-Farley, S. R.; US 6,264,937; 7/24/2001.

27. Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers. Huval; C. C.; Holmes-Farley; S. R. ; Petersen; J. S.; Dhal; P. K. ; US 6,248,318; 6/19/2001.

28. Process for removing bile salts from a patient and alkylated compositions therefore. Mandeville, W. H., III.; Holmes-Farley, S. R.; US 6,225,355; 5/1/2001.

29. Poly(diallylamine)-based bile acid sequestrants. Holmes-Farley, S. R.; Dhal, P. K.; Petersen, J. S.; US 6,203,785; 3/20/2001.

30. Polyether-Based Bile Acid Sequestrants. Holmes-Farley, S. R.; Huval, C. C.; US 6,190,649; 2/20/2001.

31. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville, W. H., III.; US 6,177,478; 1/23/2001.

32. Water-insoluble noncrosslinked bile acid sequestrants. Holmes-Farley, S. R.; Mandeville, W. H., III.; US 6,129,910; 10/10/2000.

33. Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers. Huval; C. C.; Holmes-Farley; S. R. ; Petersen; J. S.; Dhal; P. K. ; US 6,083,497; 7/4/2000.

34. Method of making phosphate-binding polymers for oral administration. Holmes-Farley, S. R.; Mandeville, W. H., III.; ; Whitesides, G. M. ; US 6,083,495; 7/4/2000.

35. Process for removing bile salts from a patient and alkylated compositions therefore. Mandeville, W. H., III.; Holmes-Farley, S. R.; US 6,066,678; 5/23/2000.

36. Process for removing bile salts from a patient and compositions therefor. Mandeville, W. H., III.; Holmes-Farley, S. R.; US 6,060,517; 5/9/2000.

37. Ionic polymers as anti-infective agents. Mandeville, III; W. H; Neenan; T. X.; Holmes-Farley; S. R. US 6,034,129; 3/7/2000.

38. Method for reducing oxalate. Holmes-Farley, S. R.; Mandeville, W. H., III.; US 5,985,938; 11/16/99.

39. Process for removing bile salts from a patient and compositions therefor. Mandeville, W. H., III.; Holmes-Farley, S. R.; US 5,981,693; 11/9/99.

40. Hydrophobic sequestrant for cholesterol depletion. Mandeville, W. H., III.; Holmes-Farley; S. R.; Petersen; J. S.. US 5,969,090; 10/19/99.

41. Hydrophilic nonamine-containing and amine-containing copolymers and their use as bile acid sequestrants. Holmes-Farley; S. R.; Petersen; J. S.. US 5,929,184; 7/27/99.

42. Interpenetrating polymer networks for sequestration of bile acids. Mandeville, W. H., III.; Holmes-Farley, S. R.; Neenan; T. X.; Whitesides; G. M. US 5,925,379; 7/20/99.

43. Amine polymer sequestrant and method of cholesterol depletion. Mandeville, W. H., III.; Holmes-Farley, S. R.; US 5,919,832; 7/6/99.

44. Process for removing bile salts from a patient and compositions therefor. Mandeville, W. H., III.; Holmes-Farley, S. R.; US 5,917,007; 6/29/99.

45. Polyamine salt hydrophobic sequestrant for cholesterol depletion. Mandeville, W. H., III.; Holmes-Farley, S. R.; Petersen, J. S.; US 5,900,475; 5/4/99.

46. Process for removing bile salts from a patient and compositions therefor. Mandeville, W. H., III.; Holmes-Farley, S. R.; US 5,840,766; 11/24/98.

47. Preparation of polymeric sequestrants for bile acid salts. Mandeville, W. H., III.; Holmes-Farley, S. R.; US 5,703,188; 12/30/97.

48. Oral administration of iron-binding crosslinked amine polymers. Mandeville, W. H., III.; Holmes-Farley, S. R.; US 5,702,696; 12/30/97.

49. Alkylated amine polymers. Mandeville, W. H., III.; Holmes-Farley, S. R.; US 5,693,675; 12/2/97.

50. Method for removing bile salts from a patient with alkylated crosslinked amine polymers, and preparation of the polymers. Mandeville, W. H., III.; Holmes-Farley, S. R.; US 5,679,717; 10/21/97.

51. Phosphate-binding polymers for oral administration. Holmes-Farley, S. R.; Mandeville, W. H., III.; US 5,667,775; 9/16/97.

52. Ion-exchange process using highly crosslinked polymers for removing bile salts from a patient, preparation of the polymers, and compositions containing them. Mandeville, W. H., III.; Holmes-Farley, S. R.; US 5,624,963; 4/29/97.

53. Hydrophobic amine polymer sequestrant and method of cholesterol depletion. Mandeville, W. H., III.; Holmes-Farley, S. R.; Petersen, J. S.; US 5,618,530; 4/8/97.

54. Amine polymer sequestrant and method of cholesterol depletion. Mandeville, W. H., III.; Holmes-Farley, S. R.; US 5,607,669; 3/4/97.

55. Phosphate-binding polymers for oral administration. Holmes-Farley, S. R.; Mandeville, W. H., III.; US 5,496,545; 3/5/96.

56. Iron-binding polymers for oral administration. Mandeville, W. H., III.; Holmes-Farley, S. R.; US 5,487,888; 1/30/96.

57. Ultra-thin, uniform sol-gel coating of a substrate having active hydrogens on the surface. Holmes-Farley, S. R.; Yanyo, L. C.; US 5,175,027; 12/29/92.

58. Layered sol-gel coatings from organisilicon compounds. Holmes-Farley, S. R.; Yanyo, L. C.; US 5,182,143; 1/26/93.

59. Method for metal bonding using ultrathin primer coating. Holmes-Farley, S. R.; Yanyo, L. C.; Thuer, A. M.; US 5,139,601; 8/18/92.

60. Acrylic adhesive compositions. Holmes-Farley, S. R.; Abbey, K. J.; US 5,096,962; 3/17/92.

61. Modified halogenatedpolyolefin adhesives for polyolefin elastomer-metal bonding. Holmes-Farley, S. R.; US 5,102,956; 4/7/92.




PUBLISHED PATENT APPLICATIONS (FOREIGN ISSUED ONLY OR NOT ISSUED)


1. Method for reducing copper levels and treating copper toxicosis. Holmes-Farley, Stephen Randall. (Geltex Pharmaceuticals, Inc., USA). PCT Int. Appl. (2002), 45 pp. WO 0285383.

2. Method for treating gout and binding uric acid. Holmes-Farley, Stephen Randall; Burke, Steven K. WO 0285381 10/31/2002.

3. Method for treating gout and reducing serum uric acid. Holmes-Farley, Stephen Randall; Burke, Steven K WO 0285380 10/31/2002.

4. Amine condensation polymer bile acid sequestrants. Huval, C. C.; Holmes-Farley, S. R.; Whitesides, G. M. WO 1999-US30469; 7/6/2000.

5. Continuous crosslinking of polymer gels. Mandeville, W. H., III and Holmes-Farley, S. R.; WO 1999-US5662; 9/23/1999.

6. Amine-containing copolymers as bile acid sequestrants. Holmes-Farley, S. R.; Petersen, J. S.; WO 9933452; 7/8/1999.

7. Polydiallylamine-based phosphate binders. Mandeville, W. H., III and Holmes-Farley, S. R.; WO 9922743; 5/14/1999.

8. Polyallylamine polymers for removing bile salts and treating hypercholesterolemia, and polymer preparation. Holmes-Farley, S. R.; Mandeville, W. H., III; Burke, S. K.; Goldberg, D. I.; WO 9857652; 12/23/98.

9. Phosphate-bidning polymers combined with a calcium supplement for oral administration. Goldberg, D. I.; Burke, S. K.; Mandeville, W. H., III; Holmes-Farley, S. R.; WO 9842355; 10/1/98.

10. Hydrophobic heteroatom-containing sequestrant for cholesterol depletion. Mandeville, W. H., III; Holmes-Farley, S. R.; Petersen, J. S.; WO 9639449; 12/12/96.

11. Process for adjusting ion concentration in a patient and compositions therefor. Mandeville, W. H., III; Holmes-Farley, S. R.; WO 9427619; 12/8/94.

12. Vacuum-deposited silver on polycarbonate with a chromium interlayer for improved metal-substrate adhesion. Holmes-Farley, S. R.; Ger. Offen. 4322512; 1/20/94.

13. Process for increased metal-substrate bond strength in metalized plastics. Holmes-Farley, S. R.; Ger. Offen. 4322516; 7/6/93.

14. Electrorheological fluids and preparation of particles useful in the fluids. Troughton, Barritt E., Jr.; Duclos, Theodore G.; Thuer, Anna Marie; Carlson, J. David; Bares, Joseph E.; Yanyo, Lynn C.; Farley, Stephen Randall Holmes; Acker, Debra Nell. EP 394049; 10/24/1990.

JOURNAL PUBLICATIONS

1. Hydroxamic acid-containing hydrogels for nonabsorbed iron chelation therapy: synthesis, characterization, and biological evaluation. Polomoscanik, Steven C.; Cannon, C. Pat; Neenan, Thomas X.; Holmes-Farley, S. Randall; Mandeville, W. Harry; Dhal, Pradeep K. Drug Discovery and Development, Genzyme Corporation, Waltham, MA, USA. Biomacromolecules (2005), 6(6), 2946-2953. Publisher: American Chemical Society.

2. Functional Polymers as Human Therapeutic Agents. Dhal, Pradeep K.; Huval, Chad C.; Holmes-Farley, S. Randall. Drug Discovery and Development, Genzyme Corporation, Waltham, MA, USA. Industrial & Engineering Chemistry Research (2005), 44(23), 8593-8604. Publisher: American Chemical Society.

3. Design and synthesis of potent small molecule inhibitors of alpha-amylase. Li, Xinhua; Nijiar, Amarjit; Mishra, Abinash; Staveski, Mark; Asmussen, Gary; Booker, Michael; Burrier, Robert; Kloss, Alla; Holmes-Farley, Randy; Mandeville, Harry; Dhal, Pradeep. Drug Discovery and Development, Genzyme Corporation, Waltham, MA, USA. Abstracts of Papers, 228th ACS National Meeting, Philadelphia, PA, United States, August 22-26, 2004 (2004), MEDI-249.


4. Molecularly imprinted bile acid sequestrants: synthesis and biological studies. Huval, Chad C.; Chen, Xi; Holmes-Farley, S. Randall; Mandeville, W. Harry; Polomoscanik, Steven C.; Sacchiero, Robert J.; Dhal, Pradeep K. Drug Discovery and Development, Genzyme Corporation, Waltham, MA, USA. Materials Research Society Symposium Proceedings (2004), Volume Date 2003, 787(Molecularly Imprinted Materials--2003), 85-90. Publisher: Materials Research Society.

5. Syntheses of hydrophobically modified cationic hydrogels by copolymerization of alkyl substituted diallylamine monomers and their use as bile acid sequestrants. Huval, Chad C.; Holmes-Farley, S. Randall; Mandeville, W. Harry; Sacchiero, Robert; Dhal, Pradeep K. Drug Discovery and Development, Genzyme Corporation, Waltham, MA, USA. European Polymer Journal (2004), 40(4), 693-701. Publisher: Elsevier Science B.V.,


6. Ammonium and Guanidinium Functionalized Hydrogels as Bile Acid Sequestrants: Synthesis, Characterization, and Biological Properties. Huval, Chad C.; Holmes-Farley, S. Randall; Mandeville, W. Harry; Petersen, John S.; Sacchiero, Robert J.; Maloney, Cynthia; Dhal, Pradeep K. Drug Discovery and Development, Genzyme Corporation, Waltham, MA, USA. Journal of Macromolecular Science, Pure and Applied Chemistry (2004), A41(3), 231-244. Publisher: Marcel Dekker, Inc.



7. Bile acid binding to sevelamer HCl. Braunlin, William; Zhorov, Eugene; Guo, Amy; Apruzzese, William; Xu, Qiuwei; Hook, Patrick; Smisek, David L.; Mandeville, W. Harry; Holmes-Farley, S. Randall. Kidney International (2002), 62(2), 611-619.

8. Amine functionalized polyethers as bile acid sequestrants: synthesis and biological evaluation. Huval, Chad C.; Bailey, Matthew J.; Holmes-Farley, S. Randall; Mandeville, W. Harry; Miller-Gilmore, Karen; Sacchiero, Robert J.; Dhal, Pradeep K. Journal of Macromolecular Science, Pure and Applied Chemistry (2001), A38(12), 1559-1574.

9. Novel Cholesterol Lowering Polymeric Drugs Obtained by Molecular Imprinting. Huval, Chad C.; Bailey, Mathew J.; Braunlin, William H.; Holmes-Farley, S. Randall; Mandeville, W. Harry; Petersen, John S.; Polomoscanik, Steven C.; Sacchiro, Robert J.; Chen, Xi; Dhal, Pradeep K. Macromolecules (2001), 34(6), 1548-1550.

10. Synthetic polymers for the binding of fat in the intestinal tract. Jozefiak, Thomas H.; Mandeville, W. Harry; Holmes-Farley, S. Randy; Arbeeny, Cynthia; Huval, Chad C.; Sacchiero, Robert; Concagh, Danny; Yang, Kanwen; Maloney, Cynthia. Abstracts of Papers, 222nd ACS National Meeting, Chicago, IL, United States, August 26-30, 2001 (2001), POLY-047 and Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) (2001), 42(2), 98.

11. Colesevelam hydrochloride: Synthesis and testing of a novel polymer gel pharmaceutical. Holmes-Farley, S. R; Mandeville, W. H.; Miller, K. L.; Petersen, J.; Ward, J.; Sacchiero, B.; Maloney, C.; Brochu, S.; Rosenbaum, D.; Goldberg, D.; Norton, K. A.; Chen, X.; Mazzeo, J. R.. Polym. Preprints (2000), 41(1), 735-736.

12. In vitro comparison of bile acid binding to colesevelam HCl and other bile acid sequestrants. Braunliin, W.; Zhorov, E.; Smisek, D.; Guo, A.; Appruzese, W.; Xu, Q.; Hook, P.; Holmes-Farley, S. R; Mandeville, H. Polym. Preprints (2000), 41(1), 708-709.

13. Novel polymeric pharmaceuticals: From startup to market. Holmes-Farley, S. R; Polym. Mater. Sci. Eng (1999), 80, 246-247.

14. Design and characterization of of Sevelamer Hydrochloride: a novel phosphate-binding pharmaceutical. Holmes-Farley, S. R.; Mandeville, W. H., III; Ward, J.; Miller, K. L.; Polym. Mater. Sci. Eng (1998), 79, 280-281 and also in J. M. S.- Pure and Appl. Chem., A36(7&8), p. 1085 (1999).

15. Three generations of bile acid sequestrants. Mandeville, W. H., III; Braunlin, W.; Dhal, P.; Guo, A.; Huval, C.; Miller, K. L.; Petersen, J.; Polomascanik, S.; Rosenbaum, D.; Sacchiero, R.; Ward, J.; Holmes-Farley, S. R.; Mat. Res. Soc. Symp. Proc. (1999), 550, 3-15.

16. Effect of RenaGel, a non-absorbable, crosslinked, polymeric phosphate binder, on urinary phosphorous excretion in rats. Rosenbaum, D. P.; Holmes-Farley, S. R.; Mandeville, W. H., III; Pitruzzello, M. .; Goldberg, D. I..; Nephrol., Dial., Transplant. (1997), 12(5) 961-964.

17. Thin anisotropic coatings based on sol-gel technology. Holmes-Farley, S. R.; Yanyo, L. C; Mater. Res. Soc. Symp. Proc. (1990), 180 (Better Ceram. Chem. 4), 439-444.

18. The mechanism of cure initiation of a surface activated adhesive. Holmes-Farley, S. R.; Minichelli, J. L.; J. Adhes. Sci. Technol. (1991), 5(5), 409-420.

19. Adhesion promotion and corrosion prevention using thin anisotropic coatings. Holmes-Farley, S. R.; Yanyo, L. C.; J. Adhes. Sci. Technol. (1991), 5(2), 131-151.

20. Wetting of functionalized polyethylene having ionizable organic acids and bases at the polymer-water interface: relations between functional group polarity, extent of ionization, and contact angle with water. Holmes-Farley, S. R.; Bain, C. D.; Whitesides, G. M.; Langmuir (1988), 4(4), 921-937.

21. Binding of phenols to aluminum oxide surfaces. 1. Phenols with a single hydroxy group. Holmes-Farley, S. R.; Langmuir (1988), 4(3), 766-774.

22. Reconstruction of the interface of oxidatively functionalized polyethylene (PE-CO2H) and derivatives on heating. Holmes-Farley, S. R.; Reamey, R. H.; Nuzzo, R.; McCarthy, T. J.; Whitesides, G. M.; Langmuir (1987), 3(5), 799-815. See also Report (1987), AD-A179590/5/GAR, Gov. Rep. Announce. Index (U. S.) 1987, 87(15).

23. Surface-modified polyethylene film: the relationship between surface chemistry and physical properties. Holmes-Farley, S. R; Diss. Abstr. Int. B 1987, 47(11), 4537.

24. Reactivity of carboxylic acid and ester groups in the functionalized interfacial region of “polyethylene carboxylic acid” (PE-CO2H) and its derivatives: differentiation of the functional groups into shallow and deep subsets based on a comparison of contact angle and ATR-IR measurements. Holmes-Farley, S. R.; Whitesides, G. M.; Langmuir (1987), 3(1), 62-76.

25. Fluorescence properties of dansyl groups covalently bonded tot he surface of oxidatively functionalized low-density polyethylene film. Holmes-Farley, S. R.; Whitesides, G. M.; Langmuir (1986), 2(3), 266-281. See also Report (1985), TR-85-2; AD-A162435/2/GAR, Gov. Rep. Announce. Index (U. S.) 1986, 86(7).

26. Acid-base behavior of carboxylic acid groups covalently attached at the surface of polyethylene: The usefulness of contact angle in following the ionization of surface functionality. Holmes-Farley, S. R.; Reamey, R. H.; McCarthy, T. J.; Deutch, J.; Whitesides, G. M.; Langmuir (1985), 1(6), 725-740.

27. The thermal stability of a surface modified solid organic polymer. Holmes-Farley, S. R.; Whitesides, G. M.; Polym. Mater. Sci. Eng. (1985), 53, 127-131.