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Unread 03/30/2003, 08:53 PM   #13
kmk2307
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Join Date: Jun 2001
Location: Tuscaloosa, AL
Posts: 5,110
Marine Toxins Origin, Structure, and Molecular Pharmacology

Hi,
I recently discovered this book at my local University Library. It has extensive information on Palytoxin (from zooanthids). There is information about antidotes to palytoxin.

Quote:
Palytoxin is one of the most potent coronary vasoconstrictors known, producing death by the iv route within minutes by diminishing the supply of oxygen to the myocardium. Tests in animals with a number of vasdilators showed that papaverine and isosorbid dinitrate are effective antidotes, but must be injected directly into the ventricle of the heart because of the speed of the action of the toxin.
Long story short:
papaverine and isosorbid dinitrate are effective antidotes according to this work.


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